Histopathology of Alagille’s Syndrome	
			
	Hepatic parenchyma	Intrahepatic bile ducts	
Before three months of age	Prominent giant cell transformation
Hepatocellular and canalicolar bilirubinostasis $
Moderate copper accumulation in periportal hepatocytes	Not or only little reduced
Mononuclear inflammatory infiltrate
Biliary epithelial degeneration $
Periductal fibrosis
	
Beyond three months of age	Less giant cell transformation
Moderate to severe bilirubinostasis $
Increased copper in periportal hepatocytes
Periportal and sinusoidal fibrosis	Paucity, up to absence, of intrahepatic bile ducts $